I charge more on a pick up from a location than a drop off, how can I setup this in LimoWiz?

Let's say you defined a service type of SEDAN which has the Add to Basic set at 0.00, just create a new service type called for example: SEDAN 1 and in the Add to Basic Rate field type for example 10.00

For Example:
If DENVILLE to JFK is  $50.00, then selecting SEDAN makes the charge $50.00
If JFK to DENVILLE is  $50.00, then selecting SEDAN 1 for Service Type makes the rate equal to $60.00